Our Research
We wish to understand basic questions such those pertaining to the physiological and metabolic pathways that regulate source‒sink relations and water homeostasis in crop plants (e.g., wheat, Arabidopsis, tomato) under changing climate conditions (e.g., more severe drought, heat, salinity). For example, differences in root morphology, root hydraulics and leaf senescence can all affect modified source‒sink relations. We applying both reverse genetics (CRISPR/CAS9) and forward genetics (genome wide association mapping and correlation network analysis combined with machine learning) approaches on crop plants (both wild and domesticated) to identify genes and pathways associated with physiological traits important for climate change scenarios.
Our Projects
We are updating the lab's current projects these days- worth waiting!
Publications
The homeostasis of β‐alanine is key for Arabidopsis reproductive growth and developmentS Wu, Y Zhang, U Luzarowska, L Yang, MA Salem, VP Thirumalaikumar, N Sade, VE Galperin, A Fernie
The Plant Journal 122 (1), e70134, 2025Available at: https://onlinelibrary.wiley.com/doi/pdf/10.1111/tpj.70134
Dynamic metabolite QTL analyses provide novel biochemical insights into kernel development and nutritional quality improvement in common wheatB Yin, J Jia, X Sun, X Hu, M Ao, W Liu, Z Tian, H Liu, D Li, W Tian, Y Hao, X Xia, N Sade, Y Brotman, AR Fernie…Plant Communications 5 (5), 2024Available at: https://www.cell.com/plant-communications/fulltext/S2590-3462(24)00001-4
Null mutants of a tomato Rho of plants exhibit enhanced water use efficiency without a penalty to yield…, N Gershon, A Dalal, F Nalufunjo, Y Dagan, L Rosental, S Abadi, Z Haber, L Silva, Y Brotman, N Sade…Proceedings of the National Academy of Sciences 121 (4), e2309006120, 2024Available at: https://www.pnas.org/doi/full/10.1073/pnas.2309006120
The reference genome and abiotic stress responses of the model perennial grass Brachypodium sylvaticumL Lei, SP Gordon, L Liu, N Sade, JT Lovell, MDM Rubio Wilhelmi, V Singan, A Sreedasyam, R Hestrin…G3: Genes, Genomes, Genetics 14 (1), jkad245, 2024Available at: https://academic.oup.com/g3journal/article-pdf/14/1/jkad245/56718702/jkad245.pdf
Plasma membrane aquaporins regulate root hydraulic conductivity in the model plant Setaria viridis…, D Sharma, J Binenbaum, P Muchaki, R Kumar, A Egbaria, KE Duarte, G Kelly, WR De Souza, N Sade Plant Physiology 193 (4), 2640-2660, 2023Available at: https://www.researchgate.net/profile/Davinder-Sharma-5/publication/373298944_Plasma_membrane_aquaporins_regulate_root_hydraulic_conductivity_in_the_model_plant_Setaria_viridis/links/67601f501da39f149578a4cd/Plasma-membrane-aquaporins-regulate-root-hydraulic-conductivity-in-the-model-plant-Setaria-viridis.pdf
The alteration of tomato chloroplast vesiculation positively affects whole-plant source–sink relations and fruit metabolism under stress conditions…, L Rosental, D Toubiana, D Sharma, S Alseekh, H Tajima, AR Fernie, Y Brotman, E Blumwald, N SadePlant and Cell Physiology 63 (12), 2008-2026, 2022Available at: https://www.academia.edu/download/111627531/pcac133.pdf
The Effect of Circular Soil Biosolarization Treatment on the Physiology, Metabolomics, and Microbiome of Tomato Plants Under Certain Abiotic StressesY Achmon, E Blumwald, JD Fernández-Bayo, Z Haber, DR Harrold, MDM Rubio Wilhelmi, N Sade…Available at: https://stacks.cdc.gov/view/cdc/231292/cdc_231292_DS1.pdf
The effect of circular soil biosolarization treatment on the physiology, metabolomics, and microbiome of tomato plants under certain abiotic stresses…, DR Harrold, JJ Stapleton, D Toubiana, JS VanderGheynst, E Blumwald, CW Simmons, N Sade…Frontiers in Plant Science 13, 1009956, 2022Available at: https://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2022.1009956/pdf
Electrical Modelling of In-Vivo Impedance Spectroscopy of NicotianaL Bar-On, U Garlando, M Sophocleous, A Jog, PM Ros, N Sade, A Avni, Y Shacham-Diamand, D DemarchiAvailable at: https://www.academia.edu/download/85862522/felec-02-753145.pdf
ABA homeostasis and long-distance translocation are redundantly regulated by ABCG ABA importers…, L Charrier, ZM Belew, N Wulff, S Damodaran, HH Nour-Eldin, A Aharoni, L Ragni, L Strader, N Sade…Science advances 7 (43), eabf6069, 2021Available at: https://www.science.org/doi/pdf/10.1126/sciadv.abf6069
Electrical modelling of in-vivo impedance spectroscopy of Nicotiana tabacum plantsL Bar-On, U Garlando, M Sophocleous, A Jog, P Motto Ros, N Sade, A Avni, Y Shacham-Diamand, D DemarchiFrontiers in Electronics 2, 753145, 2021Available at: https://www.frontiersin.org/journals/electronics/articles/10.3389/felec.2021.753145/pdf
Genomic basis underlying the metabolome-mediated drought adaptation of maizeF Zhang, J Wu, N Sade, S Wu, A Egbaria, AR Fernie, J Yan, F Qin, W Chen, Y Brotman, M DaiGenome Biology 22 (1), 260, 2021Available at: https://link.springer.com/article/10.1186/s13059-021-02481-1
Guard cells control hypocotyl elongation through HXK1, HY5, and PIF4…, A Egbaria, O Stein, A Doron-Faigenboim, N Lugassi, E Belausov, H Zemach, F Shaya, N Carmi, N Sade…Communications Biology 4 (1), 765, 2021Available at: https://www.nature.com/articles/s42003-021-02283-y.pdf
A cytoplasmic receptor-like kinase contributes to salinity tolerance N Sade, F Weng, H Tajima, Y Zeron, L Zhang, MM Rubio Wilhelmi, G Day, Z Peleg, E BlumwaldPlants 9 (10), 1383, 2020Available at: https://www.mdpi.com/2223-7747/9/10/1383
Measuring the hydraulic conductivity of grass root systemsA Gal, E Hendel, Z Peleg, N Schwartz, N SadeCurrent Protocols in Plant Biology 5 (2), e20110, 2020
Tomato yellow leaf curl virus (TYLCV)-resistant tomatoes share molecular mechanisms sustaining resistance with their wild progenitor Solanum habrochaites but not with TYLCV-susceptible tomatoes D Sade, N Sade, Y Brotman, H CzosnekPlant Science 295, 110439, 2020Available at: https://www.sciencedirect.com/science/article/am/pii/S0168945220300418
Correlation-based network analysis combined with machine learning techniques highlight the role of the GABA shunt in Brachypodium sylvaticum freezing toleranceD Toubiana, N Sade, L Liu, MM Rubio Wilhelmi, Y Brotman, U Luzarowska, JP Vogel, E BlumwaldScientific Reports 10 (1), 4489, 2020Available at: https://www.nature.com/articles/s41598-020-61081-4.pdf